Due to climate change, the agri-food system is increasingly exposed to risks which contribute to food and nutrition insecurity. Climate-resilient, water-efficient, and self-sustainable agri-food systems are the only viable approach for the future. Locally sourced fertilizers and closed-looped hydroponic farming systems are attractive solutions for several reasons: reuse, and reduction of water resources, use of natural and optimized fertilizers, and controlled, more predictable and improved food security, independent of the climate change. Indoors and outdoors hydroponic systems, while being efficient technologies, still require a source of fertilizers.